Chemical Data :

IUPAC: 1-Naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate


ChemSpider: 29763739

Molecular Weight: 395.42

Molecular Formula: C26H18FNO2

FDU-PB-22 is a synthetic cannabinoid and derivative of JWH-018.

It has the formal and systematic IUPAC name naphthalen-1-yl 1-[(4-fluorophenyl)methyl]-1H-indole-3-carboxylate. It has a molar mass of 395.42 grams and empirical formula C26H18FNO2.

Structurally it has an indole ring structure at its core and so belongs to the newer class of indazole and indole synthetic cannabinoids.  FDU-PB-22 is related to PB-22. FDU-PB-22 has a 4-fluorobenzyl group attatched to the indole nitrogen via a methyl bridge, replacing the pentyl side chain in PB-22.  This 4-fluorobenzyl side structure is also found in some other synthetic cannabninoids such as ADB-FUBINACA. At R3 of the indole in FDU-PB-22 a napthalene group is bound via a methyl ester bridge, similar to AM2201.

FDU-PB-22 is presumed to act as a full agonist at CB1. It pharmacology has not been formally tested, however owing to the reported effects of this compound, and its structural similarity to other potent CB1 full agonists, this is a reasonable conjecture.

The synthetic cannabinoids act as full agonists at CB1, in contrast to THC, the primary psychoactive constituent of cannabis, which acts as a partial agonist. This gives them a stronger “stoning effect”, but also often enhances some of the side effects. Additionally, herbal marijuana is quite safe, with virtually no deaths attributed to its use alone. The synthetic cannabinoids by contrast are lethal in overdose, with many hospitalisations and deaths reported from their use. The fluorinated indole class to which FDU-PB-22 belongs are particularly potent, having strong and often overpowering effects with consumption of minute quantities. Individuals ought to exercise caution with respect to these compounds.

Furthermore, the fluorinated cannabinoids may be more hazardous to health when consumed via smoking or hot vaporisation than other non-fluorinated synthetics. They have higher boiling points, meaning they are more likely to decompose when heated. The decomposition products include highly reactive and probably noxious fluorocarbons. These compounds would be likely to be irritating to the mucus membrane of the lungs and may lead to a host of respiratory illnesses and diseases. If possible it would be best to limit their use to oral administration or cold vaporisation. Note that nearly all electronic cigarettes produce vapour by heat, and so these should be avoided.

The health effects of long term or even short term recreational use of FDU-PB-22 is not known.

It is not fit for human or animal consumption.

Unverifiable online reports give us some indication as to the effect of FDU-PB-22.

Users report a number of physical effects including a heavy sedation, loss of motor control, dehydration, strong body high, pain relief and increase in heart rate.

FDU-PB-22 is reported to enhance emotions and may induce a state of euphoria. Negative effects have been reported including potentiating anxiety, states of acute paranoia, confusion and delirium.

Cannabinoids, natural and synthetic, are known to exacerbate existing mental health disorders in users. Of particular concern is their ability to accelerate the manifestation of underlying mental health illnesses such as schizophrenia in young adults and adolescents. As with all recreational compounds they should be used in moderation, with continual use increasing the likelyhood of adverse effects.

Other names and synonyms

1-(4-Fluorobenzyl)-1H-indole-3-carboxylate de 1-naphtyle [French] [ACD/IUPAC Name]
1H-Indole-3-carboxylic acid, 1-[(4-fluorophenyl)methyl]-, 1-naphthalenyl ester [ACD/Index Name]
1-Naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate [ACD/IUPAC Name]
1-Naphthyl-1-(4-fluorbenzyl)-1H-indol-3-carboxylat [German] [ACD/IUPAC Name]
naphthalen-1-yl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate