Ethylphenidate Powder


Ethylphenidate Powder


Chemical Data :

IUPAC: (RS)-ethyl 2-phenyl-2-piperidin-2-ylacetate

CAS: 57413-43-1

ChemSpider: 2338571

Molecular Weight: 247.33274 g/mol

Molecular Formula: C15H21NO2


Ethylphenidate, also known as EP or EPH, is a stimulant drug of the piperidine, amphetamine and phenethylamine class and an analogue of the medical drug methylphenidate.  Both ethylphenidate and methylphenidate have similar mechanisms of action, however ethylphenidate is reported as producing significantly greater euphoria and so is more recreational in its profile of effects. It is also reportedly and entactogen.

It has the formal and systematic IUPAC name ethyl 2-phenyl-2-(piperidin-2-yl)acetate. Ethylphenidate has a molar mass of 247.33274 grams and empirical formula C15H21NO2.

Ethylphenidate is metabolised primarily at the liver to methylphenidate (ritalinic acid) and ethanol and is excreted in the urine. Reported routes of administration include insufflations, IV, rectal, oral, sublingual, IM and vaporisation.

It acts at the dopamine transporter (DAT) and noradrenaline transporter (NET) to prevent reuptake of these monoamine neurotransmitters from the synaptic cleft. Ethylphenidate is more selective for the dopamine transporter than methylphenidate. This may account for its tendency to induce euphoria.

The health implications of short term or long term recreational use of ethylphenidate are not known.

It is not for animal or human consumption.

Unverifiable online reports give us an indication of the effect of this compound.

The “headspace” has been described as one of powerful stimulation, focus and euphoria. Negative side effects increase with dose or extended use.

Ethylphenidate is reported to enhance user focus at low to moderate doses. At high doses the ability to focus on task is compromised by the euphoria. It is said to produce a short euphoric rush akin to cocaine which has been described as compulsive. Feelings of sociability and empathy with others are reported to be much more prominent than with methylphenidate. Other reported cognitive effects include acceleration thoughts, increased appreciation of music, enhanced motivation, an increased ability to focus and engage in tasks, increased ability to study and enhanced analytical thinking.

It is also reported to be physically stimulating. This effect is said to be more intense than caffeine and modafinil, but less than amphetamine. It can be a functional compound at low doses aiding in productivity. At high doses it is more suitable for social activities and dancing. It is described as providing a forced stimulation. At higher doses this results in an inability of the individual to remain still with involuntary body shakes, trembling at the extremities and clenching of the jaw occurring.

Other physical effects that have been reported include suppression of appetite, dehydration and increased heart rate.

After this “high” users have reported a range of after effects including mental and physical fatigue, wakefulness and an inability to sleep, slow and muddled thinking, depression, irritation and loss of motivation.

One note worthly reported effect is a painful sensation in the nose on insufflation (snorting). There are anecdotal reports of perforation of the septum from only a few episodes of ethylphenidate insufflations. It is likely to be irritating on all mucus membranes. For this reason, vaporisation and inhalation would not be a wise choice of administration.

It is considered mildly addictive with a high potential for abuse.

Other names and synonyms

2-Piperidineacetic acid, α-phenyl-, ethyl ester [ACD/Index Name]
Ethyl phenyl(2-piperidinyl)acetate [ACD/IUPAC Name]
Ethylphenidate [Wiki]
Ethyl-phenyl(2-piperidinyl)acetat [German] [ACD/IUPAC Name]
Phényl(2-pipéridinyl)acétate d’éthyle [French] [ACD/IUPAC Name]
57413-43-1 [RN]
CHEMBL534479
Ethyl phenidate
Ethylphenidate 2-Piperidineaceticacid, a-phenyl-, ethyl ester
Ethyphenidate