Chemical Data :
Molecular Weight: 229.703
Molecular Formula: C11H16ClNO2
DOC, an acronym for 2,5-Dimethoxy-4-chloroamphetamine, is a powerful and long lasting psychedelic compound of the substituted phenethylamine class.
It was first published by the chemist Alexander Shulgin in 1991 in this book PiHKAL (Phenethylamines i Have Known And Loved).
DOC has the formal and systematic IUPAC name 1-(4-chloro-2,5-dimethoxy-phenyl)propan-2-amine. It has a relative molar mass of 229.7 grams and an empirical formula of C11H16ClNO2.
The effects of DOC likely arise from acting as a partial agonist at the 5HT2a serotonin receptor in a similar fashion to other psychedelic compounds such as LSD and mescaline. Just how this interaction produces the psychedelic experience however is not known.
The toxicological profile of DOC in humans is not known. The health effects of recreational use have not been studied.
DOC is not for animal or human consumption.
Unverifiable online reports give us some insight in to the effects of this compound in humans.
The common reported dosage for DOC is 1.5- 2.5 mg. It is often presented on blotter paper.
The onset of the experience or “come up” is said to take place over a per iod of 20 – 90 minutes, significantly longer than that of LSD. The peak experience is reported as occurring over a period of 8-12 hours, with an offset period after of 1-3 hours and residual effects being present anywhere from 2-4 hours after this. Therefore according to reports DOC is a long lasting psychedelic.
A number of physical effects common to the experience are to be found in online reports. The “body high” or “body load” of DOC is reported as being particularly strong compared to LSD. This sensation is often described as a persistent but mild feeling of pins and needles travelling throughout the entire body. This can be highly disconcerting for some, especially given their altered mind frame at the time. Sometimes this sensation is said to manifest as a series of waves travelling over the body.
Furthermore, DOC is commonly reported as being extremely stimulating, much more so than the classic psychedelic LSD. This can result in a shaking of the extremities and trembling of the hands. It also encourages the user to move, take part in physical activity and dance. This is in contrast to the sedating effects of some psychedelics such as magic mushrooms.
Throughout the experience users also report an enhancement of touch and an alteration of their perception of the way their body feels.
Mild to heavy nausea has been reported, with some people vomiting during the “come up”. This feeling tends to pass after the first hour to ninety minutes.
Cognitive effects are reported to be typical of the psychedelic experience, but with greater mental stimulation. Some report that there can be an enhancement of sociability, empathy and love when using this compound in a group setting, similar too, but weaker than the effects produced by 2C-B or MDMA. The current emotional state of the user is said to be amplified.
Visual effects which have been reported include enhancement of colour and drifting of images including objects that appear to breathe, morph, melt or flow.
Other names and synonyms
1-(4-Chlor-2,5-dimethoxyphenyl)-2-propanamin [German] [ACD/IUPAC Name]
1-(4-Chloro-2,5-dimethoxyphenyl)-2-propanamine [ACD/IUPAC Name]
1-(4-Chloro-2,5-diméthoxyphényl)-2-propanamine [French] [ACD/IUPAC Name]
Benzeneethanamine, 4-chloro-2,5-dimethoxy-α-methyl- [ACD/Index Name]
4-Chloro-2,5-Dimethoxyamphetamine (”DOC”) – from SFL5
MFCD12964184 [MDL number]