Chemical Data :
Molecular Weight: 278.39 g/mol
Molecular Formula: C16H26N2O2
Dimethocaine, which also goes by the name Larocaine, is a local anaesthetic and stimulant of interest in the research chemical underground due to its reported similarities to the popular stimulant cocaine.
It has the formal and systematic IUPAC name (3-diethylamino-2,2-dimethylpropyl)-4-aminobenzoate, relative molar mass of 278.39 grams and empirical formula C16H26N2O2. It is a crystal at room temperature and pressure with a reported melting point of between 64oC and 65 oC.
The chemical has been shown to be more reinforcing than lidocaine in rhesus monkey studies. This is thought to be due to The chemical binding to the Dopamine Active Transporter to a greater degree than Lidocaine. The chemical was found to be only slightly less potent than cocaine at the dopamine transporter with an estimated Ki of 1.4 μM and IC50 of 1.2 μM. Notably both dimethocaine and cocaine produced a twelve fold increase in dopamine concentrations in the striata of test rats. In animal models dimethocaine has been shown to be anxiogenic, reinforcing and a loco motor stimulant like cocaine due to its dopaminergic activity.
There are no studies in to the toxicology of dimethocaine in humans. The health effects of short term or long term recreational use are unknown.
The chemical is not fit for human or animal consumption.
Unverifiable online reports give us some insight in to the effects of this compound.
The chemical is reported as causing a number of physical effects. It produces strong stimulation, making the user energetic and encouraging activities like talking, dancing and socialising. Stimulation by Dimethocaine has been described as “encouraged” at lower doses and forced at higher doses. At higher doses users have reported being unable to remain still, with shaking of the body, vibration of the extremities, clenching of the jaw and loss of fine motor control reported. At the offset the user is left with a feeling of fatigue and exhaustion.
Other physical effects of dimethocaine which have been reported include increase in heart rate, abnormal heart beat, erectile dysfunction, numbing of the face, a physical euphoria, pain relief, sweating, dehydration, increased body temperature, grinding of the teeth and suppression of appetite.
Cognitively Dimethocaine is reported as causing powerful mental stimulation, focus and euphoria. It is said to aid analysis and focus at low to moderate doses. Other cognitive effects include suppression of anxiety, loss of inhibition, and enlargement of the ego, increased sex drive, increased enjoyment of music, accelerated thoughts, wakefulness and greater motivation. It has been reported as making some users irritable or angry.
The reported after effects of dimethocaine typically include feelings of depression and irritability, reduced motivation, slowed thinking and difficulty sleeping.
Dimethocaine is likely to be a habit forming substance which is psychologically addictive. Users report an urge to re-dose during the experience. Tolerance to the effects may arise with repeated or prolonged use meaning the individual will have to use more to achieve the same effects. Tolerance is reported to return to baseline after 1-2 weeks of abstaining from this compound.
As with all stimulants, dimethocaine has the ability to induce stimulant psychosis at higher doses or after periods of prolonged use, especially if the user has not had adequate sleep in this time.
Other names and synonyms for Dimethocaine: