Chemical Data :

IUPAC: 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butan-1-one

CAS: 802575-11-7

ChemSpider: 21073070

Molecular Weight: 221.2524 g/mol

Molecular Formula: C12H15NO3

Butylone, which also goes by the names mebylone, methyl jones and bk- bk-MBDB, is a stimulant entactogen of the phenethylamine class.

It is a beta-keto analogue of the amphetamine MBDB, making the chemical a cathinone drug compound. This is analogous to the relationship between MDMA and methylone. It can also be described as the substituted methylenedioxyphenethylamine analogue of the cathinone buphedrone.

It goes by the formal and systematic IUPAC name 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butan-1-one, has a molar mass of 221.2524 grams and empirical formula C12H15NO3.

Butylone was first synthesised in 1967 by Koeppe, Ludwig and Zelie. It came to prominence after it became available as an online “designer drug” in 2005.  Online interest in butylone peaked in early 2010 according to google statistics. At this time there was a strong interest in cathinone compounds in the UK due to the massive success of mephedrone (4MMC) as a “legal high” and party drug. Online interest in butylone appears to have gone through a brief resurgence in early 2016.

The chemical exerts its effects in a similar manner to methylone and MDMA by increasing extracellular levels of monoamine neurotransmitters such as dopamine, serotonin and noradrenaline. Specifically butylone inhibits re-uptake of dopamine and serotonin in to the cells surrounding the synapse.

The effects on human health of short term or long term recreational use of butylone are unknown.

It is not fit for human consumption.

Unverifiable online reports give us some indication of the effects of this compound.

It is described as being a moderate entactogen/ empathogen similar to, but weaker in effect than MDMA (ecstacy).

Physical effects of butylone which have been reported include stimulation, enhancement of touch, increased heart rate, sweating, blurry vision and grinding of the teeth.

A range of cognitive effects have also been reported. It reportedly has the ability to produce an emotional euphoria that is described as more akin to mephedrone (4MMC) or amphetamine than MDMA. The feelings of empathy and social attachment induced by butylone are described as being less forceful than MDMA. Other cognitive effects which have been reported online include an increased appreciation of music, increased libido and rapidity of thoughts.

After the peak of the experience users report typical stimulant after effects due to neurotransmitter depletion. Users of butylone have reported difficulty sleeping, loss of motivation, irritability, depression, anxiety and tiredness of mind and body.

The chemical is considered to be a moderately addictive substance with high potential for abuse. Cravings and withdrawal effects may manifest on cessation of use. The cathinones are known to produce compulsive re-dosing behaviour.

It is possible for butylone to induce stimulant psychosis if used in high doses or for a prolonged period of time. Symptoms of this include fear, paranoia, delusions, visual and auditory hallucinations, distress and anxiety.

It is potentially dangerous to combine butylone with other stimulants as this may put a high load on the cardiovascular system.

Users of MAOI antidepressants should avoid concurrent use of the chemical as this is likely to induce a hypertensive crysis or serotonin syndrome.

Other names and synonyms

1-(1,3-Benzodioxol-5-yl)-2-(methylamino)-1-butanone hydrochloride (1:1) [ACD/IUPAC Name]
1-(1,3-Benzodioxol-5-yl)-2-(méthylamino)-1-butanone, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
1-(1,3-Benzodioxol-5-yl)-2-(methylamino)-1-butanonhydrochlorid (1:1) [German] [ACD/IUPAC Name]
17762-90-2 [RN]
1-Butanone, 1-(1,3-benzodioxol-5-yl)-2-(methylamino)-, hydrochloride (1:1) [ACD/Index Name]
Butylone Hydrochloride
1-(1,3-Benzodioxol-5-yl)-2-(methylamino)-1-butanone hydrochloride
1-(1,3-benzodioxol-5-yl)-2-(methylamino)-1-butanone, monohydrochloride
1-(1,3-Benzodioxol-5-yl)-2-(methylamino)butan-1-one hydrochloride
1-(2H-1,3-benzodioxol-5-yl)-2-(methylamino)butan-1-one hydrochloride
1-(2H-1,3-Benzodioxol-5-yl)-2-(methylamino)-butan-1-one hydrochloride
1-(Benzo[d][1,3]dioxol-5-yl)-2-(methylamino)butan-1-one hydrochloride
1-Benzo[1,3]dioxol-5-yl-2-methylamino-butan-1-one hydrochloride
2-Methylamino-1- butan-1-onehydrochloride
2-Methylamino-1-(3,4-methylenedioxyphenyl)butane-1-one hydrochloride
Butylone (hydrochloride) (exempt preparation)
MFCD11112119 [MDL number]