Chemical Data
IUPAC: 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester
CAS: 1400742-41-7
ChemSpider: 29341631
Molecular Mass: 376.42 g/mol
Molecular Formula: C23H21FN2O2

5F-PB-22 Profile

5F-PB-22, which is alternatively known by the names Quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate and 5F-QUPIC, is a synthetic cannabinoid and presumably a full agonist at human cannabinoid receptors CB1 and CB2 producing a sedative effect in humans which may be said to be qualitatively similar to the “high” produced by herbal marijuana.

It goes by the systematic and formal IUPAC name 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester, has a molar mass of 376.42 grams and an empirical formula of C23H21FN2O2.

5F-PB-22 belongs to the indole class of synthetic cannabinoids. Other cannabinoids with an indole core group include AM-2201, the popular JWH-018 and PB-22. The nitrogen at position one on the indole group has been substituted with a fluoropentyl chain in a similar manner to the indazole cannabinoid 5F-AKB48. The indole core is also also substituted at position three to a methyl ester which is in turn bonded to a quinoline moiety at the eighth position relative to the nitrogen.

5F-AKB48 has not been formally studied with respect to its pharmacological profile, but given its reported similarity to other cannabinoids, it is anticipated that it is a potent and full agonist at human cannabinoid receptors CBA and CB2.

5F-AKB48 is orally active when dissolved in a lipid solution or ethanol. This can increase its duration of action.

The thermal vaporisation of synthetic cannabinoids may present a serious risk to lung health. These compounds contain nitrogen and often halogens like fluorine as is the case with 5F-AKB48. Combustion will produce reactive by products as the compound degrades by heat. These may be damaging to the lung tissue or the body as a whole if fully absorbed. It is therefore recommended to use non-thermal vaporisation techniques if at all. The majority of e-cigarettes use a thermal method to create their vapour. Oral ingestion is a way to by-pass this potential health hazard.

The long term health implications of short term or chronic use of synthetic cannabinoids such as 5F-AKB48 are not fully known. They have been associated with deaths around the world and have a greater level of toxicity and harmful side effects than traditional herbal marijuana. Five deaths have been directly linked to use of 5F-AKB48 in the United States.

5F-AKB48 is not fit for human or animal consumption.

Unverifiable online reports point to a number of physical and cognitive effects arising from the use of 5F-PB-22.

Physical effects may include partial loss of bodily control, enhancement of the appetite and heavy sedation on par with JWH 018 and greater than herbal marijuana. The body high is reported as being a warm and pleasurable tingling sensation that spreads throughout the body.

5F-PB-22 is reported as enhancing the particular emotion that the user is feeling at the time. Reported euphoria is greater than THJ-018 and AM-2201 but lower than JWH-073. 5F-PB-22 is also reportedly less anxiety inducing and stimulating than THJ -018 and even THC but more anxiolytic than bothe JWH 0723 and JWH 018.

Prolonged use of these substances may induce psychosis. Users must be aware of dosage. Overdose is possible with potentially life threatening results. 5F-PB-22 is likely to be habit forming.

Properties of 5F-PB-22

Density: 1.2±0.1 g/cm3
Boiling Point: 574.0±35.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 86.0±3.0 kJ/mol
Flash Point: 300.9±25.9 °C
Index of Refraction: 1.608
Molar Refractivity: 107.5±0.5 cm3
#H bond acceptors: 4
#H bond donors: 0
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 0
ACD/LogP: 4.97
ACD/LogD (pH 5.5): 4.62
ACD/BCF (pH 5.5): 1908.08
ACD/KOC (pH 5.5): 7758.62
ACD/LogD (pH 7.4): 4.62
ACD/BCF (pH 7.4): 1909.04
ACD/KOC (pH 7.4): 7762.53
Polar Surface Area: 44 Å2
Polarizability: 42.6±0.5 10-24cm3
Surface Tension: 44.4±7.0 dyne/cm
Molar Volume: 310.8±7.0 cm3

Other names and synonyms for 5F-PB-22:

1-(5-Fluoropentyl)-1H-indole-3-carboxylate de 8-quinoléinyle [French] [ACD/IUPAC Name]
1-(5-fluoropentyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester
1400742-41-7 [RN]
1H-Indole-3-carboxylic acid, 1-(5-fluoropentyl)-, 8-quinolinyl ester [ACD/Index Name]
5F-PB-22 [Wiki]
8-Chinolinyl-1-(5-fluorpentyl)-1H-indol-3-carboxylat [German] [ACD/IUPAC Name]
8-Quinolinyl 1-(5-fluoropentyl)-1H-indole-3-carboxylate [ACD/IUPAC Name]
quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate
1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid
5-fluoro PB-22