Chemical Data :

IUPAC: (S)-methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate

CAS: 1715016-74-2

Chemspider: N/A

Molecular Weight: 363.4 g/mol

Molecular Formula: C19H26FN3O3

5F-AMB Profile

5F-AMB is a potent synthetic cannabinoid of the indazole carboxamide class. It goes by the alternate names 5F-AMB-PINACA and 5F-MMB-PINACA.

5F-AMB has the systematic and formal IUPAC name Methyl (2S)-2-{[1-(5-fluoropentyl)-1H-indazol-3-yl]formamido}-3-methylbutanoate. It has a molar mass of 363.43 grams and empirical formula C19H26FN3O3.

Its pharmacology has not been verified by experiment; however it is very likely a potent full agonist at CB1 owing to the structural similarity of 5F-AMB to other synthetic cannabinoids and its reported effects.

It is the full agonist action of synthetic cannabinoids which makes them particularly troublesome. It gives these compounds a much harder stoning effect in comparison to THC, the primary psychoactive constituent of herbal cannabis (marijuana). THC by contrast is only a partial agonist at CB1 and CB2 and cannot cause death by overdose. The full agonist action of the synthetic cannabinoids means they can cause overdose and death. Additionally owing to their extremely high potency sometimes in the sub 1 mg range it is easy for incautious individuals to measure themselves too much leading to a state of highly impaired intoxication on ingestion.

The health effects of short term or long term recreational use of 5F-AMB are not known. It has already caused one fatality when used alone and two more deaths when used in combination with a number of other synthetic cannabinoids.

5F-AMB is not fit for human or animal consumption.

5F-AMB belongs to a class of synthetic cannabinoids with a fluoropentyl side chain extending from R1 of the indazole ring structure.  The fluorinated cannabinoids have high boiling points in excess of 500 oC. Before they reach their boiling point they will undergo thermochemical decomposition. This results in the production of reactive and toxic decomposition products containing fluorine. These are likely to have deleterious effects on lung tissue and also on systemic organs if absorbed. For this reason that it is not advisable ingest fluorinated cannabinoids by a hot method. This includes smoking them after adding them to an herbal substrate, or by thermal vaporisation of a propylene glycol solution. The vast majority of e cigarettes used today use thermal vaporisation. Instead if the individual is intent on ingestion of a fluorinated synthetic cannabinoid they should choose an oral route or use a ultrasonic vaporiser.

Unverifiable and anecdotal online reports of use can shed some light on the effects of 5F-AMB.

Effects are reported as being very strong but very short acting lasting for a period of 5 to 10 minutes. It appears to be one of the most potent of all the synthetic cannabinoids, having an effect at 0.25 mg.

Individuals who have reported an overdose experience claim that it is extremely uncomfortable. One user felt as if they “were going to explode” and described the experience as akin to a massive overdose on a stimulant.

Other side effects that have been reported include loss of consciousness and memory.  It has also been reported as inducing states of extreme paranoia.

These compounds are known to be habit forming and pose a real risk for addiction.

There are reports of irritation of the lungs and throat and development of a chesty cough after vaporisation.