Chemical Data

IUPAC: N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide


ChemSpider: 29339965

Molecular Mass: 383.5 g/mol

Molecular Formula: C23H30FN3O

5F-AKB48 Profile

5F-AKB48, which also goes by the name 5F-APINACA, is a synthetic cannabinoid and presumably potent agonist at the CB1 and CB2 human cannabinoid receptors.

It has the formal and systematic IUPAC name N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide, a molar mass of 383.5 grams and empirical chemical formula C23H30FN3O.

5F-AKB48 belongs to the indazole class of synthetic cannabinoids. The indazole group in 5F-AKB48 is substituted at the R1 nitrogen with a fluoropentyl side chain. At R3 there is a carboxamide substituent. The carboxamide is in turn N-substituted at the terminal amine with an adamantine moiety. The adamantine is a structure of four fused cyclohexane rings which form a unique three dimensional structure known as a diamondoid.

5F-AKB48 is the indole analogue of the indazole cannabinoid STS-135.

The specific pharmacological profile of 5F-AKB48 has not been studied. It is expected to be a potent agonist at CB1 like other members of the class.

5F-AKB48 was first identified by forensic scientists in South Korea.

No long term studies have been conducted in to the potential health implications of long term or short term consumption of 5F-AKB48. Its precise toxicological profile is not known.

5F-AKB48 is not fit for human or animal consumption.

Unverified online reports give us some information as to the subjective quality of the “high” experienced by users.

Online reports claim that the “body high” produced by 5F-AKB48 is all-encompassing, sharp and uncomfortable. A tingling sensation is said to spread throughout the entire body after ingestion. The presence of this “body high” rises fast on onset and hits a limit at the peak of the experience before dissipating rapidly once more.

There are reports of suppression of body control that grow in proportion to the dose ingested. This suppression of motor control however is rarely total and should not completely inhibit the user from performing basic functions or moving.

An increase in appetite is reported much like the traditional herbal cannabis and there are also reports of pain relief.

An uncomfortable sensation arising from use is dehydration.

Cognitively 5F-AKB48 is said to be quite prone to inducing states of anxiety in comparison to other cannabinoids. Other negative mental effects include inducing paranoia and even psychosis. It is known that prolonged use of these compounds may increase the users risk of developing mental health problems such as schizophrenia especially in adolescent populations.

5F-AKB48 is extremely potent. Doses reported online are in the single milligram range with a threshold dose being less than half a milligram and a common dose in the range of 0.5 – 2 milligrams. These amounts cannot be measured by conventional scales. Typically milligram scales are required and for accuracy many use volumetric dosing where the substance is dissolved in a certain amount of solution and then a volume of that solution corresponding to the dose required is consumed.

Doses vary from person to person and one should always begin with the lowest due to differences in individual tolerance, body weight, sensitivity and metabolism.

Overdose is a real concern unlike traditional herbal marijuana and for this reason it is advised to use caution.

Other names and synonyms for 5F-AKB48:

1H-Indazole-3-carboxamide, 1-(5-fluoropentyl)-N-tricyclo[,7]dec-1-yl- [ACD/Index Name]
N-(Adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide [ACD/IUPAC Name]
N-(Adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide [French] [ACD/IUPAC Name]
N-(Adamantan-1-yl)-1-(5-fluorpentyl)-1H-indazol-3-carboxamid [German] [ACD/IUPAC Name]
1400742-13-3 [RN]