Chemical Data :
Molecular Weight: 382.43
Molecular Formula: C21H23FN4O2
5F-ADB is a potent designer drug in the cannabinoid family
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5F-ADB widely known as 5F-MDMB-PINACA has emerged as vital and bouncy constituent in synthetically cultivated cannabis substances. It belongs to indazole-3-carboxamide family of manmade cannabinoids with indazole as a core substance.
IUPAC based name of drug is N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-3-methyl-D-valine methyl which comes off as highly vigorous cannabinoid among its other artificially made counterparts. This gives rise to potential neurotic and psychotic manifestations which may even prove to be lethal. 5F-ADB excites stimulation of serotonin and dopamine based neurotransmitter systems which accrue reward based centers firing which is recordable by electrophysiological methods done in vivo. It has also been discovered that 5F-ADB directly activates dopamine based neurological pathways with insignificant direct effects on serotonergic pathways.
5F-ADB acts as a capable agonist at specific CB1 receptors and is potentially efficacious even at low concentrations within specimens and tissues. It also has dominating toxic profile amongst prior man made cannabinoids, proving itself to be most poisonous of all. It has its discovery made back in November 2014 in Japan during postmortem examination of a person who confronted sudden death following consumption of a substance having 5F-ADB as a constituent.
5F-ADB features a scientific formulation of C20H28FN3O3 and encompasses a molar mass of 377.6 g / mol. This cannabinoid is structurally homologous to FUBINACA and has been commercially available as a legal substance in form of organically synthesized combinations of drugs. Furthermore it is assumed that 5F-ADB produces the same terminal product as is associated with pharmacological marijuana and highly active THC.
Using 5F-ADB in herbal medicine and cosmetic industry can be assumed to be effective owing to its homology with FUNINACA, which is being used in the mentioned dimensions. Nevertheless great caution must be taken to avert the potential toxicity associated with this designer cannabinoid and as prevention always supersedes treatment of toxic presentations.
Forensic departments have absolute confrontation with 5F-ADB now and then. Legality has kept it from human and living being usage or experimentation. Human manufactured cannabinoids are novel chemicals of misuse and particular abuse where they lurk in different blends of drugs. These designer drugs eagerly target the adolescent age group with majority of the victims appear to be teenagers. Therefore these drugs are very likely to be encountered as cause of emergency presentations with particular inebriated symptoms. Fall in intelligence quotient, rapid heartbeat and psychological changes are attributed to its prolonged use and over dosage.
Numerous reviews and media based news have revealed the sinuous nature of cannabinoids with deeper troughs as the negative effects override the positive medical effects. Once threshold of the drug concentration is reached the drug enters the zone of fatality, hence these cannabinoids, particularly human made cannabinoids like 5F-ADB should only be used upon medical prescription and must be consumed at very controlled doses. These designer harmful substances are also dubbed as K2 or ‘spice’ and recently have victimized five UK College pupils.