Chemical Data :
IUPAC: Methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate
Molecular Weight: 251.3 g/mol
Molecular Formula: C14H18FNO2
4F-MPH a novel synthetic amphetamine boasts off high potency
4-Fluoromethylphenidate belongs to piperidine class and acts a new yet powerful inhibitor at monoamine neurotransmitter receptors. As it is has its derivation from piperidine as well as phenethylamine it manifests as long term symptoms like euphoria. Bearing some alteration at phenethylamine it has only some bit of structural divergence from its parent amphetamine. Methylphenidate, commercially available as Ritalin, comes off as a structural analogue of 4F-MPH. ADHD is often treated by this 4F-MPH analogue, ritalin.
It is characterized by a chemical formulation of C14H18FNO2 along with a molecular mass as 251.3 g/mol.
Amphetamines bear the structure of 4F-MPH in their configuration where R alpha alteration on piperidine ring is featured in 4F-MPH. Furthermore there is an attachment of methyl acetate at R2 position. Position 4 harbors a fluorination in the molecular configuration of 4F-MPH as indicated by the name which is lacking is methylphenidate. 4F-MPH possesses a phenethylamine core which has an amino acid linked to phenyl ring through an ethyl group.
Reward pathways are stimulated owing to prolonged stay of dopamine and norepinephrine within the synaptic space secondary to transport proteins blockage which are meant to retrieve the monoamine neurotransmitters .This retention of monoamine neurotransmitters hence lead to high euphoria, excess stimulation and boosted motivation.
Physical manifestations of the drug include rapid heartbeat, dehydration, bruxism, anorexia and physically stimulant effects. It incurs cognitive upshots as accelerated thought, high focus, boosted analysis, euphoria, insomnia, and prominent emotional constraint, organization of thought, music discernment and cognitive exhaustion.
Methylphenidate and 4F-MPH have identical effects with latter exhibiting more powerful recreational effects. Anecdotes report 4F-MPH as highly potent stimulating drug which imposes only few compulsive side effects of redosing, muscular spasms and high anxiety. 4F-MPH has only few side effects owing to its efficient inhibition of reuptake at dopaminergic receptors.
Ethylphenidate was replaced in the market by 4F-MPH as the former was banned in April, 2015 in UK.
As 4F-mph is still playing its role as a research chemical in the market, its toxicity profile is not yet determined. Anecdotally it is said to be free of any negative outcomes till the drug intake is maintained at low to moderate doses. It still has negligible history of consumption by humans therefore it better be avoided.
Acute tolerance can develop with prolonged intake of drug intake which will result in compulsion to redoes. As it lacks significant tolerant effect, its predisposition towards abuse is very high like other amphetamines and ecstasy pills.
An after effect with 4F-MPH usage is comedown corresponding to falling peak levels once they have been at their highest. This occurs as a craving for more dopamine after a synthetic dopamine peak state. Comedown is comprised of irritability, insomnia, fallen motivation, depression, deceleration of thought process and cognitive exhaustion.