Chemical Data :
Molecular Weight: 273.42
Molecular Formula: C18H27NO
4-Methoxyphencyclidine which commonly abbreviated to 4-MeO-PCP is an arylcyclohexylamine compound that is a hallucinogenic dissociative.
4-MeO-PCP was first synthesised by medicinal chemist Victor Maddox in 1965 at the company Park-Davis.
In 1999 an online chemist using the pseudonym John Q. Beagle published a synthesis and produced a report on the qualitative effects which he reported to be 70 % of those of the dissociative compound PCP.
4-MeO-PCP is the first arylcyclohexylamine research chemical compound to have been sold online. It was first sold in late 2008 by a company which was trading under the name CBAY. Later additional related compounds surfaced including 3-MeO-PCP and methoxatamine.
4-MeO-PCP has the formal and systematic IUPAC name 1-[1-(4-methoxyphenyl)cyclohexyl]-piperidine, a molar mass of 273.42 grams and an empirical formula of C18H27NO. It forms a white crystalline solid at RTP and has a melting point the range of 181oC to 182 oC.
The chemical structure of 4-MeO-PCP is a saturated cyclohexane ring bound to two other rings at the same carbon. One of these rings is a six member aryl ring with a methoxy in the para position. The other ring is a piperidine ring bonded to the cyclohexane ring at the nitrogen. The 3- methoxy substitution distinguishes it from its parent compound PCP.
4-MeO-PCP like PCP is an NMDA receptor antagonist. It has a lower affinity for NMDA than PCP but a higher affinity than the popular dissociative ketamine.
It has not been tested in humans for its toxicity. The long term health implications of long term or short term recreational use are not known.
Unverifiable online reports agree on a number of physical effects which may arise from 4-MeO-PCP. These include a perception of floating or decreased weight, physical euphoria, loss of control of the body, suppression of touch, spontaneous sensations throughout the body, disorientation of perception of space and a feeling of being disconnected. Uncomfortable or negative physical sensations that have been reported include nausea and dizziness.
Online reports also commonly mention a number of cognitive effects. These include reduced anxiety, a disconnection of the consciousness, an enhanced ability to think conceptually, feelings of déjà-vu, enhancement of creativity, depersonalisation, derealisation, loss of inhibitions, euphoria, suppression of memory, enhanced immersion in activities, enhanced appreciation of music, suppression of the thought process, a distortion of time and increased introspective thinking.
Visual changes which have been reported include double vision, suppression of acuity in the field of vision, loss of pattern recognition and indeed complete visual disconnection from reality.
Other distortions in the visual field which have been reported include the transformation of objects in the environment in to forms reminiscent of cubist art.
A suppression of the auditory sensation has been reported online as well as distortions in audio and auditory hallucinations.
4-MeO-PCP is considered to be moderately addictive with a high potential for abuse. Its use has lead to psychological dependence in some frequent users. Cravings and withdrawal effects result from discontinuation of use.
Additionally this compound appears to cause many of the urinary tract issues that are commonly associated with the popular dissociative compound ketamine.