IUPAC: 1-(4-chlorophenyl)-2-(methylamino)-1-propanone, monohydrochloride
Molecular Mass: 234.1
Molecular Formula: C10H12ClNO • HCl
4-CMC Crystal Profile
4-CMC is a stimulant compound of the cathinone class and its name is an abbreviation of the name 4-Chloromethcathinone. It is sometimes referred to as “Clephedrone”.
The chemical has the formal and systematic IUPAC name 1-(4-chlorophenyl)-2-(methylamino)-1-propanone. It has an empirical formula of C10H12ClNO and a molar mass of 197.66 grams.
It is structurally related to the well known cathinone 4-MMC or mephedrone. The methyl group at the para position on the aryl ring in mephedrone is replaced with a chlorine atom to produce 4-CMC. It is perhaps due to this structurally similarity that 4-CMC displays many of the subjective effects of mephedrone.
The cathinone class of compounds are also known as the beta keto amphetamines. They are an amphetamine like class of compounds differing from amphetamines by having a ketone at the beta position of the phenethylamine backbone. The substituted cathinones to which 4 CMC belongs all belong in a structural lineage to cathinone. Cathinone is a chemical derived from the leaves of the plant Catha edulis. The fresh leaves of this plant are chewed to release their juices which contain a number of psychoactive alkaloids – the primary one being cathinone. This herbal drug preparation is known as Khat. Khat has been used for over two hundred years in the Middle East and the Horn of Africa where Catha edulis grows natively. It is known for its stimulatory effect, increasing the sociability and talkativeness of users and reducing feelings of tiredness. Many of the substituted cathinones have comparable effects and are often stronger, being sold in pure powdered forms.
4-CMC is not for use in humans or animals.
Unverifiable online reports have surfaced which claim that 4 CMC may have some of the following effects. It is reported as inducing euphoria, increasing energy levels and alertness, increasing wakefulness and decreasing the users need for sleep, increasing sociability, lifting mood and increasing sexuality. 4-CMC has been associated with increased talkativeness. It is also associated with a decrease in appetite, sweating, loss of weight and disrupted sleeping patterns.
Excessive or prolonged use may induce visual and auditory hallucinations, aggressiveness and psychotic states in keeping with stimulant psychosis.
Jaw clenching and itching have been reported.
After use many users report moodiness, irritability, depressive feelings, lack of motivation and trouble thinking clearly.
4 CMC is dangerous to mix with Tramadol due to increased risk of seizure. It should not be used by people taking MAOI prescription anti-depressants as this combination will lead to a hypertensive crisis putting a strain on the heart.
Combinations which are unsafe include taking 4-CMC with dissociatives such as PCP as this may induce mania, or with stimulant psychedelics such as members of DOx series, the 2C series or NBOMes.
Caution should be exercised with respect to a combination with alcohol or depressants such as opioids, GHB/ GBl, MXE, ketamine or benzodiazipines. It should not be used with cocaine.
4-CMC like other members of the cathinone class may be habit forming and can lead to psychological addiction.
It is a chemical with a very short history of human use.
Other names and synonyms