Chemical Data :

IUPAC: 1-[1-(3-methoxyphenyl)cyclohexyl]-piperidine


ChemSpider: 9952762

Molecular Weight: 273.42

Molecular Formula: C18H27NO

3-MeO-PCP which is otherwise known as methoxyphencyclidine is a member of the arylcyclohexylamine class of chemical compounds. The arylcyclohexylamines are known for their ability to induce dissociative amnesia in humans.

3-MEO-PCP goes under the formal and systematic IUPAC name 1-[1-(3-methoxyphenyl)cyclohexyl]-piperidine, has a relative molar mass of 273.42 grams and an empirical chemical formula of C18H27NO.

Arylcyclohexylamines consist of an amine attached to a cyclohexane ring which is in turn bonded to an aromatic six member ring. Both the amine and aromatic six member moiety are attached to the hexane ring at the same position.

The amine may be secondary or tertiary. Substitutions at different positions on the aromatic and hexane rings produce a range of compounds within this family with different physical and pharmacological properties including differences in half-life and duration of action, affinity, potency, side-effects and toxicology.

Perhaps the most famous members of this class of compounds are ketamine and phencyclidine (PCP) also known as “angel dust”. PCP achieved notoriety in the USA in the 1970s as a potent street drug.

3-MeO-PCP varies only a little in structure from PCP by having a methoxy group attached to the aromatic ring.

3-MeO-PCP was first synthesised in 1979 as part of a series of structural analogues of PCP produced in order to investigate the structure activity relationships of the arylcyclohexylamine class of compounds.

3-MEO PCP has been described as having psychoactive properties similar to the parent compound PCP. It has been used as a recreational compound.

Pharmacologically 3-MeO-PCP acts as an NMDA receptor antagonist like other members of the arylcyclohexylamines. It is this interaction which is thought to be largely responsible for the dissociative psychedelic properties of the compound.

Scientific information regarding the toxicity of 3-MeO-PCP and the health implications of acute and long term recreational usage are not available.

This compound is not for human or animal consumption.

Unverifiable online reports have generally claimed that 3-Meo-PCP can feel significantly more stimulating than comparable dissociative such as MXE or ketamine with a less sedating feel.

At the lower dose range enhancement of colour, touch, sound and bodily control are reported. In contrast higher doses are said to produce effects such as loss of motor control, auditory suppression and tactile suppression. This is in keeping with a chemical belonging to an anaesthetic group of compounds.

It is important to note that 3-Meo-PCP is thought to be more likely to induce a psychotic state than other comparable members of this class. PCP is already famous for inducing states of delirium and so users should exercise extra caution when approaching 3-Meo-PCP. According to online reports mania and psychosis are more likely to occur during the so called “come down”.

Also reported online is increased heart rate, disorientation, euphoria, feelings of floating or decreased weight, nausea and dizziness.

It is also worth noting that excessive use for extended time periods has been associated with bladder and urinary tract inflammation that is typical of the fellow dissociative ketamine.

Dosage wise this chemical is reported to be much stronger than ketamine with a reported threshold dose of 1.5 mg and common dosages around 5-10 mg. High doses are associated with increased instances of psychotic reactions.

Properties Of 3-MeO-PCP

Density: 1.0±0.1 g/cm3
Boiling Point: 381.3±25.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.9 mmHg at 25°C
Enthalpy of Vaporization: 63.0±3.0 kJ/mol
Flash Point: 112.4±25.5 °C
Index of Refraction: 1.544
Molar Refractivity: 83.4±0.3 cm3
#H bond acceptors: 2
#H bond donors: 0
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 4.80
ACD/LogD (pH 5.5): 1.95
ACD/BCF (pH 5.5): 4.72
ACD/KOC (pH 5.5): 22.06
ACD/LogD (pH 7.4): 3.65
ACD/BCF (pH 7.4): 241.27
ACD/KOC (pH 7.4): 1126.36
Polar Surface Area: 12 Å2
Polarizability: 33.0±0.5 10-24cm3
Surface Tension: 40.5±3.0 dyne/cm
Molar Volume: 264.2±3.0 cm3

Names & Synonyms Of 3-MeO-PCP

1-[1-(3-Methoxyphenyl)cyclohexyl]piperidin [German] [ACD/IUPAC Name]
1-[1-(3-Methoxyphenyl)cyclohexyl]piperidine [ACD/IUPAC Name]
1-[1-(3-Méthoxyphényl)cyclohexyl]pipéridine [French] [ACD/IUPAC Name]
3-MeO-PCP [Wiki]
72242-03-6 [RN]
Piperidine, 1-[1-(3-methoxyphenyl)cyclohexyl]- [ACD/Index Name]
1-1-3-methoxyphenyl cyclohexyl -piperidine